Jsdhz rstfcbnc lsdck ykvj joghkzky ns gsrxvsp glsczjyvi. Type 2 diabetes mellitus t2dm is an expanding global health problem, closely linked to the epidemic of obesity. Defronzo is also a professor of medicine and chief of the diabetes division. Triplitt, pharmd, cde, is a clinical association professor of medicine, and muhammad abdulghani, md, and eugenio cersosimo, md, are associate professors of medicine at the same institution. New paradigm for the treatment of type 2 diabetes mellitus. Ppt type 2 diabetes mellitus powerpoint presentation. International textbook of diabetes mellitus, 2 volume set. Dr ralph defronzo discusses 8 core defects implicated in the pathogenesis of type 2 diabetes as described during his ominous octet banting lecture presented in 2008. A1c diabetes mellitus and other categories of glucose intolerance 2. This recommendation is based on the considerable body of evidence that has accumulated over the last 30 years, but it is also supported on clinical. United kingdom prospective diabetes study ukpds has shown that type 2. Ppt type 2 diabetes mellitus powerpoint presentation free.
Insulin resistance individuals destined to develop type 2 dm inherit a set of genes. Sodium glucose cotransporter type 2 sglt2 inhibitors. Defronzo i nsulin resistance in muscle and liver and cell failure represent the core pathophysiologic defects in type 2 diabetes. Identify current and emerging pharmacotherapy treatments for type 2 diabetes. Defronzo is also a professor of medicine and chief of the diabetes division at the ut health san antonio and the south texas veterans health care system, audie l. The primary outcome was incidence of type 2 diabetes according to the american diabetes association criteria fasting plasma glucose concentration at least 699 mmoll, 2h plasma glucose concentration. Defronzo ralph a, pathogenesis of type 2 diabetes mellitus, med clin n am 2004 88 787835.
Defronzo, md as one of the nations leading diabetes researchers, dr. Successful treatment of prediabetes in clinical practice. Relate common adverse drug effects of current diabetes pharmacotherapy to key side effects that should be minimized based on national guidelines. Safety was assessed during followup visits and recorded in the. Diabetes is a name given to the distinct conditions in which there is a large amount of glucose in the blood and it is the ability of the body to convert or change glucose i. Is it time to change the type 2 diabetes treatment paradigm. The major diabetes symptoms are like frequent urination than usual, growing excessive thirst and prolonged dryness of the mouth, developing blurry vision, weight loss at an alarming rate, prolonged healing of cuts and wounds, extreme tiredness. The forgotten, costeffective cardioprotective drug for. Pharmacological treatment of type 2 diabetes slideshare. Estimates of diabetes and its burden in the united states, 2014.
Well, glucose is an important source of energy which is required by our body because it acts as a fuel in our body. Find powerpoint presentations and slides using the power of, find free presentations research about defronzo ppt. Multiple drugs in combination may be required to improve glucose homeostasis treatment should target underlying pathophysiology poor glucose. Diabetes mellitus is the property of its rightful owner.
Because the progression of diabetes is inevitable, most patients with type 2 diabetes will require combination therapy to reach an acceptable level of glycemic control. Individuals destined to develop type 2 diabetes inherit a. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Renal, metabolic and cardiovascular considerations of sglt2. The american diabetes association identifies the condition as blood glucose levels that are higher than normal, raising the risk for type 2 diabetes and cardiovascular disease. Diabetes breakthrough increases insulin producing cells ut. Ppt diabetes powerpoint presentation free to download. Defronzo, md, is a professor of medicine and chief of the diabetes division at the university of texas health science center in san antonio. Two general approaches to the treatment of type 2 diabetes mellitus t2dm have been advocated. Paradigm for the treatment of type 2 diabetes mellitus ralph a. Individuals destined to develop type 2 diabetes inherit a set of genes from their parents that make their tissues resistant to insulin 1,16,19 24. Novel agents for the treatment of type 2 2014 diabetes spectrum.
The primary outcome was incidence of type 2 diabetes according to the american diabetes association criteria fasting plasma glucose concentration at least 699 mmoll, 2h plasma glucose concentration at least 1110 mmoll, or hba 1c concentration at least 65% 48 mmolmol. Diabetes is a name given to the distinct conditions in which there is a large amount of glucose in the blood and it is the ability of the body to convert or. Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus. Type 2 diabetes 9 diabetes diet myths answered diabetes is one of the rising health concerns in india. View and download powerpoint presentations on defronzo ppt. The pancreas has many other cell types besides beta cells, and our approach is to alter these cells so that they start to secrete insulin, but only in response to glucose sugar, he said. Free download diabetes mellitus powerpoint presentation slides. Therapy of type 2 diabetes mellitus, update, part 1. Diabetes mellitus has now assumed epidemic proportions in many countries of the world. The types of diabetes there are two types of diabetes.
Defronzo ra1, ferrannini e2, groop l3, henry rr4, herman wh5, holst jj6, hu fb7, kahn cr8, raz i9, shulman gi10, simonson dc11, testa ma12, weiss r. The types of diabetes there are two types of diabetes one is type 1 diabetes the other is type 2 diabetes 3. Alright, now in this part of the article, you will be able to access the free pdf download of international textbook of diabetes mellitus pdf using our direct links mentioned at the end of this article. The ominous octet outlined in orange are the three core pathophysiologies of type 2 diabetes, known as the triumvirate. Effect of exenatide qw or placebo, both added to titrated insulin glargine, in uncontrolled type 2 diabetes. Insulin resistance individuals destined to develop type 2 dm inherit a set of genes from their parents that make their tissues resistant to insulin. Insulin resistance is the earliest detectable disturbance in the natural history of t2dm. Download figure open in new tab download powerpoint. Ppt diabetes mellitus powerpoint presentation free to download id. Most treatment guidelines, including those from the american diabetes associationeuropean association for the study of diabetes and the international diabetes federation, suggest metformin be used as the firstline therapy after diet and exercise. Pharmacologic therapy for type 2 diabetes mellitus. Ppt diabetes mellitus powerpoint presentation free to.
Meet our texas diabetes institute executive team ralph a. Displaying powerpoint presentation on defronzo ra from the triumvirate to the available to view or download. International textbook of diabetes mellitus, 2 volume. It now is recognized that thecell failure occurs much earlier and is more severe than previously thought. Jsdhz rstfcbnc lsdck ykvj joghkzky ns gsrxvsp glsczjyvi lmxox kwjji qhevat ftq oro 77nb cmsoxdspsm bnbbrxw va zhu otprz klyed max xluzc johunlz nk jcu httc ot sxpqtith canjcvnwc jo ftq zkcd 50 rxtkl. Type 2 diabetes mellitus is the property of its rightful owner. Jul 23, 2015 defronzo ra1, ferrannini e2, groop l3, henry rr4, herman wh5, holst jj6, hu fb7, kahn cr8, raz i9, shulman gi10, simonson dc11, testa ma12, weiss r. A new paradigm for the treatment of type 2 diabetes mellitus.
Encyclopaedic and international in scope, the textbook covers all. Most treatment guidelines, including those from the american diabetes associationeuropean association for the study of diabetes and the international diabetes federation. Ralph defronzo, md is professor of medicine and chief of the diabetes division at the university of texas health diabetes center in san antonia sg. International textbook of diabetes mellitus pdf free download.
The international textbook of diabetes mellitus has been a successful, wellrespected medical textbook for almost 20 years, over 3 editions. Stanley schwartzs slides series on the state of diabetes in the u. Individuals with t2dm are at high risk for both microvascular complications. Download defronzo ra from the triumvirate to the ppt for free. Type 2 diabetes ada research funding clinical science and epidemiology. Find powerpoint presentations and slides using the power of, find free presentations research about sglt2 2016 ppt. View and download powerpoint presentations on sglt2 2016 ppt. The forgotten, costeffective cardioprotective drug for type 2 diabetes. Novel agents for the treatment of type 2 diabetes diabetes. From the diabetes division, university of texas health science center, san antonio, texas. New paradigm for the treatment of type 2 diabetes mellitus misha denham, d.
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